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Using Nanotechnology to Target Aggressive Cancers
A modified gold nanoparticle is used to target aggressive triple negative breast cancer and melanoma by inhibiting RAD6 which is overexpressed in aggressive and chemo resistant cancers.
Technology Summary
This technology utilizes gold nanoparticles (GNPs) conjugated with a small molecule inhibitor (SMI#9) designed to target RAD6, a protein overexpressed...
Published: 9/26/2025
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Inventor(s): Malathy Shekhar, Guangzhao Mao, Yanhua Zhang
Keywords(s): Breast Cancer, Driving Lifelong Health, Nanotechnology
Category(s): Technology Category > Therapeutics, Technology Category > Oncology, Technology Category > Nanomaterials, Technology Category > Life Science, Technology Category > Drug Delivery, Technology Category > Cancer, Technology Category > Women's Health
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EL4-E2 Cell Line
This technology is a targeted anti-HER2 cell line that can be used as a research tool to develop HER2‑based vaccines for the treatment of aggressive breast cancer.
Background & Unmet Need:
The human epidermal growth factor 2 (HER2) is overexpressed in approximately 20-30% of all breast cancers and is associated with more aggressive and...
Published: 9/15/2025
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Inventor(s): Wei-Zen Wei
Keywords(s): Breast Cancer
Category(s): Technology Category > Research tools, Technology Category > Life Science, Technology Category > Cell lines, Technology Category > Biological materials
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Transgenic Mice Carrying Wild Type Human Her-2 Under the Whey Acidic Promoter
This transgenic line expresses the human ERBB2 (HER2) gene in mammary gland and brain, displays tolerance to ERBB2 antigen and may be useful in testing ERBB2-based vaccines and immunotherapies.
Technology Summary
Her-2 positive breast cancer is a breast cancer that is positive for a protein called human epidermal growth factor receptor 2 (Her-2)....
Published: 9/26/2025
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Inventor(s): Wei-Zen Wei, Ye-Shih Ho, Marie Piechocki
Keywords(s): Animal Model, Breast Cancer, Driving Lifelong Health, Research Tool
Category(s): Technology Category > Research tools, Technology Category > Life Science, Technology Category > Animal models
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