Search Results - analog or analogue




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Inhibitors of the ubiquitin E3 ligase BCA2 as anti-cancer therapeutic agents
Background:Breast cancer associated protein 2 (BCA2) is a ubiquitin E3 ligase found in invasive breast cancer. Studies have shown that by decreasing its activity, breast cancer cell growth and invasiveness are diminished. Targeting this ligase and inhibiting its activity could play a role in treatment of breast cancer. A molecular approach to in...
Published: 8/3/2017   |   Inventor(s): Angelika Burger, Andrew Westwell
Keywords(s): Analog or Analogue, Breast Cancer, Cancer, Disease, Drug Target, Enzyme
Category(s): Diseases, Oncology, Therapeutics, Life Science, Research tools
Anti-Cancer Activity of a 2,5-Substituted Pyrimidine
This technology is a novel class of compounds that induce apoptosis in cancerous cells. BackgroundARR molecules (adamantyl-substituted retinoid-related) are a unique class of compounds which have been found to induce apoptosis, or cell death, in a large number of tumor types. SHP plays a role in cellular proliferation. Molecules that Interfere wi...
Published: 8/3/2017   |   Inventor(s): Joseph Fontana, Ramzi Mohammad, Lulu Farhana, Amro Aboukameel, Marcia Dawson, Zebin Xia
Keywords(s): Analog or Analogue, Anti-cancer
Category(s): Life Science, Oncology, Therapeutics, Diseases
Antibacterial activity of natural compounds and their synthetic analogue: A potential new antibiotic with potent activity against multiple drug resistant bacterial pathogens
Our researchers have developed novel compounds that are potential antibiotics useful for treatment against the deadly bacteria MRSA (methicillin-resistant Staphylococcus aureus), VRE (vancomycin-resistant Enterococcus faecium), and several other well-known common infectious agents.Background & Unmet Need:Before antibiotics became available in t...
Published: 5/12/2015   |   Inventor(s): Fazlul Sarkar, Hossein Salimnia, Subhash Padhye, Bernhard Biersack
Keywords(s): Analog or Analogue, Antibiotics, Anti-infective, Anti-microbial, Disease
Category(s): Biologicals, Diseases, Infectious disease, Life Science, Therapeutics