Imaging Tandem Mass Spectrometry: Reduction to Practice

Case ID:

Currently, tandem mass spectrometry is typically performed by selecting a single mass peak in a time of flight or quadrupole mass spectrometer, which is then fragmented through collision, after which the products are mass-selected in a quadrupole or similar secondary mass spectrometer. A Wayne State University researcher has developed an alternative approach which records the full 2-D tandem mass spectrum at once, revealing the correlations between the mass speaks formed in the first and second step. Velocity map imaging is coupled with pulsed electric deflection in a reflectron configuration to achieve spatially-resolved mass dispersion without the use of magnetic fields. Furthermore, when orthogonal deflection pulses are employed with an intervening fragmentation step such as laser induced fragmentation, then a two-dimensional image of the full tandem mass spectrum is obtained at once.

Commercial Applications

·         Tandem mass spectrometry is proteomics applications and disease diagnosis

Technological Advantages

·         Improves sensitivity and accuracy of mass spectrometry by recording a full 2-D tandem mass spectrum at once, whereas current applications rely on one-dimensional data recording

Patent Status

U.S. Patent 7,534,996

Tech ID


Patent Information:
For Information, Contact:
Nicole Grynaviski
Commercialization Principal
Wayne State University
Arthur Suits
Myung Kim
Brian Leskiw