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Disulfide by Design 2.0: A web-based tool for disulfide engineering in proteins
Background:Immunoinformatics employs a computer-driven approach to identifying fragments of the target pathogen that would provide a suitable vaccine, avoiding potential safety concerns from the more traditional approach of using whole pathogens. Immunoinformatics now plays a crucial role in vaccine design, immunodiagnostic development, and antibody...
Published: 9/15/2025
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Inventor(s): Alan Dombkowski, Douglas Craig
Keywords(s): Coronavirus, COVID-19
Category(s): Technology Category > Software, Technology Category > Simulation & Modeling, Technology Category > Research tools, Technology Category > Protein/peptides, Technology Category > Life Science, Technology Category > Computer Software
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Microfluidic platforms for live-cell imaging and bio/pathomimetic tissue models
Background:Methodologies to image and quantify tissue models using high-content analysis (HCI) and functional analyses of 3D avatars are needed as such avatars better recapitulate the phenotype of pathobiological processes and better predict efficacy of, and resistance to, a wide variety of therapies. Furthermore, changes in morphometry, viability,...
Published: 9/15/2025
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Inventor(s): Bonnie Sloane, Kamiar Moin, Kyungmin Ji, Kingsley Osuala, Yong Xu, Hongen Tu
Keywords(s):
Category(s): Technology Category > Specialty compounds, Technology Category > Research tools, Technology Category > Oncology, Technology Category > Microfluidics, Technology Category > Life Science, Technology Category > Instrumentation, Technology Category > Imaging, Technology Category > Diseases, Technology Category > Devices, Technology Category > Cell lines
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Polyclonal and Monoclonal Antibodies to TPH1 and TPH2
This technology is a set of antibodies that is used with immunohistochemistry techniques to differentiate between tryptophan hydroxylase 1 and 2, enabling scientists to study how the two enzymes are differentially regulated.
Technology Summary
The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode enzymes in serotonin biosynthesis. Variants...
Published: 9/26/2025
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Inventor(s): Donald Kuhn
Keywords(s): Antibody, Assay, Driving Lifelong Health, Immunoassay
Category(s): Technology Category > Research tools, Technology Category > Life Science, Technology Category > Biological materials, Technology Category > Research tools > Antibodies
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EL4-E2 Cell Line
This technology is a targeted anti-HER2 cell line that can be used as a research tool to develop HER2‑based vaccines for the treatment of aggressive breast cancer.
Background & Unmet Need:
The human epidermal growth factor 2 (HER2) is overexpressed in approximately 20-30% of all breast cancers and is associated with more aggressive and...
Published: 9/15/2025
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Inventor(s): Wei-Zen Wei
Keywords(s): Breast Cancer
Category(s): Technology Category > Research tools, Technology Category > Life Science, Technology Category > Cell lines, Technology Category > Biological materials
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Transgenic Mice Carrying Wild Type Human Her-2 Under the Whey Acidic Promoter
This transgenic line expresses the human ERBB2 (HER2) gene in mammary gland and brain, displays tolerance to ERBB2 antigen and may be useful in testing ERBB2-based vaccines and immunotherapies.
Technology Summary
Her-2 positive breast cancer is a breast cancer that is positive for a protein called human epidermal growth factor receptor 2 (Her-2)....
Published: 9/26/2025
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Inventor(s): Wei-Zen Wei, Ye-Shih Ho, Marie Piechocki
Keywords(s): Animal Model, Breast Cancer, Driving Lifelong Health, Research Tool
Category(s): Technology Category > Research tools, Technology Category > Life Science, Technology Category > Animal models
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Generation of gp78 null mice
Generation of gp78 null mice
WSU Tech#: 15-1291
Technology:
Generation of the first preclinical experimental model system for gp78-/- C57BL/6 mice, which spontaneously develops age-related nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), linking endoplasmic reticulum-associated degradation (ERAD) to hepatosteatosis, cirrhosis,...
Published: 9/15/2025
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Inventor(s): Avraham Raz, Andrei Golovko
Keywords(s):
Category(s): Technology Category > Research tools, Technology Category > Oncology, Technology Category > Life Science, Technology Category > Genomics/Genetics, Technology Category > Drug Screening, Technology Category > Drug Delivery, Technology Category > Drug Discovery, Technology Category > Biomedical, Technology Category > Biotechnology, Technology Category > Biology, Technology Category > Animal models
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"Generation of an affinity-purified rabbit anti-CREBH polyclonal antibody"
Generation of an Affinity-Purified Rabbit Anti-CREBH Polyclonal Antibody WSU Tech#: 15-1271Technology Summary: CREBH (also called CREB3L3) is a stress-inducible metabolic regulator that plays key roles in hepatic lipolysis, fatty acid oxidation, gluconeogenesis, and lipogenesis. CREBH is critically involved in fatty liver disease and its associated...
Published: 9/15/2025
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Inventor(s): Kezhong Zhang
Keywords(s):
Category(s): Technology Category > Research tools, Technology Category > Assays, Technology Category > Research tools > Antibodies
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Lyophilized Ready to Use & Load PCR Master Mix
PCR and Enzyme Lyophilization and Stabilization Formulation WSU Tech#: 13-1183Technology Summary: Wayne State University has discovered methods in which to formulate PCR related enzymes and reagents so they can be lyophilized. This stabilizes the proteins, nucleotides and buffers so they can be shipped and stored at room temperature. Our research...
Published: 9/15/2025
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Inventor(s): Jian-Ping Jin
Keywords(s):
Category(s): Technology Category > Research tools, Technology Category > Life Science, Technology Category > Biological materials
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GENERATION OF 5-FLUOROURACIL + OXALIPLATIN RESISTANT COLON CANCER CELLS: A TOOL TO STUDY CANCER RECURRENCE AND DRUG RESISTANCE
Generation of 5-Fluorouracil + Oxaliplatin Resistant Colon Cancer Cells
WSU Tech#: 13-1154
Technology Summary:
A significant obstacle for the successful management of patients with colorectal cancer (CRC) is intrinsic drug resistance or, in patients who respond to chemotherapy, acquired drug resistance. Drug resistance can occur through a variety...
Published: 9/15/2025
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Inventor(s): Adhip Majumdar, Yingjie Yu
Keywords(s):
Category(s): Technology Category > Research tools, Technology Category > Oncology, Technology Category > Drug Discovery, Technology Category > Characterization, Technology Category > Cell lines, Technology Category > Biotechnology, Technology Category > Biomedical
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CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines
CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines
WSU Tech#: 15-1256
Technology Summary:
CJ4.1A and CJ4.3C are rat conjunctival epithelial cell lines. The cell lines were developed to investigate antigen translocation across a mucosal barrier. Conjuctival epithelial cells from Fischer 344 rats were immortalized with pSV3(neo) resulting...
Published: 9/15/2025
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Inventor(s): Nancy O'sullivan, Alfred Baylor Iii, Paul Montgomery
Keywords(s):
Category(s): Technology Category > Research tools, Technology Category > Life Science, Technology Category > Cell lines
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