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Isoform-selective HDAC inhibitors
Selective C4-modified SAHA analogs inhibit HDAC6 and HDAC8 enzymes for targeted therapeutic applications.
Technology Summary
Histone deacetylase (HDAC) proteins are key players in cancer progression and have emerged recently as targets for anti-cancer drugs. WSU researchers have synthesized a variety of small molecule HDAC...
Published: 6/16/2026
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Inventor(s): Mary Pflum
Keywords(s):
Category(s): Technology Category > Biomedical, Technology Category > Chemical Processing/Synthesis, Technology Category > Characterization, Technology Category > Life Science, Technology Category > Oncology, Technology Category > Pharmaceuticals, Technology Category > Research tools, Technology Category > Small molecule
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Cell permeable ATP analogs
A novel ATP analog featuring a polyamine linker enables efficient kinase-catalyzed biotinylation within live cells by enhancing cell permeability.
Technology Summary
ATP (adenosine 5’-triphosphate) analogs such as ATP-biotin are widely used to monitor biochemical events in vitro. WSU researchers developed a specially...
Published: 6/16/2026
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Inventor(s): Mary Pflum
Keywords(s):
Category(s): Technology Category > Assays, Technology Category > Biology, Technology Category > Life Science, Technology Category > Research tools, Technology Category > Chemical Processing/Synthesis
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Human Tissue-Engineered Inflammatory Model of Atherosclerosis
A novel, biologically engineered human blood vessel model that accurately replicates atherosclerosis for advanced preclinical research.
Technology Summary
This technology creates the first authentic human tissue-level in vitro model of atherosclerosis using a proprietary ring stacking method to build three-layered blood vessels entirely from human...
Published: 1/9/2026
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Inventor(s): Mai Lam
Keywords(s):
Category(s): Technology Category > Biomedical, Technology Category > Research tools, Technology Category > Simulation & Modeling, Technology Category > Driving Lifelong Health, Technology Category > Cardiology, Technology Category > Biomaterials, Technology Category > Life Science
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Transgenic Mouse Model for Marfan Syndrome Research
Description:
A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025
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Inventor(s): Li Li, Shichao Wu, Jiawei Zhao
Keywords(s):
Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic
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Disulfide by Design 2.0: A web-based tool for disulfide engineering in proteins
Background:Immunoinformatics employs a computer-driven approach to identifying fragments of the target pathogen that would provide a suitable vaccine, avoiding potential safety concerns from the more traditional approach of using whole pathogens. Immunoinformatics now plays a crucial role in vaccine design, immunodiagnostic development, and antibody...
Published: 3/10/2026
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Inventor(s): Alan Dombkowski, Douglas Craig
Keywords(s): Coronavirus, COVID-19
Category(s): Technology Category > Software, Technology Category > Simulation & Modeling, Technology Category > Research tools, Technology Category > Protein/peptides, Technology Category > Life Science, Technology Category > Computer Software
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Polyclonal and Monoclonal Antibodies to TPH1 and TPH2
This technology is a set of antibodies that is used with immunohistochemistry techniques to differentiate between tryptophan hydroxylase 1 and 2, enabling scientists to study how the two enzymes are differentially regulated.
Technology Summary
The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode enzymes in serotonin biosynthesis. Variants...
Published: 12/10/2025
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Inventor(s): Donald Kuhn
Keywords(s): Antibody, Assay, Driving Lifelong Health, Immunoassay
Category(s): Technology Category > Research tools, Technology Category > Life Science, Technology Category > Biological materials, Technology Category > Research tools > Antibodies
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Transgenic Mice Carrying Wild Type Human Her-2 Under the Whey Acidic Promoter
This transgenic line expresses the human ERBB2 (HER2) gene in mammary gland and brain, displays tolerance to ERBB2 antigen and may be useful in testing ERBB2-based vaccines and immunotherapies.
Technology Summary
Her-2 positive breast cancer is a breast cancer that is positive for a protein called human epidermal growth factor receptor 2 (Her-2)....
Published: 9/26/2025
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Inventor(s): Wei-Zen Wei, Ye-Shih Ho, Marie Piechocki
Keywords(s): Animal Model, Breast Cancer, Driving Lifelong Health, Research Tool
Category(s): Technology Category > Research tools, Technology Category > Life Science, Technology Category > Animal models
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Whole body model of a 10-year-old child for pediatric injury prediction
Technology
A computational whole body 10-year-old (YO) FE (Finite Element) model which is anatomically accurate based on the clinical images. The model was composed ofhigh quality elements for accurate stress/strain predictions and possessed high biofidelity to accurately predict body responses under external mechanical loadings. Preliminary verification...
Published: 9/15/2025
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Inventor(s): Haojie Mao, King-Hay Yang
Keywords(s):
Category(s): Technology Category > Research tools, Technology Category > Automotive & Transportation
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Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging
Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI...
Published: 10/1/2025
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Inventor(s): Sarah Trimpin
Keywords(s): Biotechnology, Imaging
Category(s): Technology Category > Spectroscopy, Technology Category > Research tools, Technology Category > Physical Sciences, Technology Category > Other, Technology Category > Instrumentation, Technology Category > Life Science, Technology Category > Imaging, Technology Category > Characterization
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SIRT2 Antibody
This technology is a novel rabbit antibody for SIRT2 ( Sirtuin 2) designed to follow human SIRT2 proteins in order to determine their role in gene regulation and apoptosis.Background & Unmet Need:The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress...
Published: 9/15/2025
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Inventor(s): Michael Tainsky, Sylvia Dryden
Keywords(s): Compound, Protein
Category(s): Technology Category > Research tools, Technology Category > Life Science, Technology Category > Diagnostic, Technology Category > Research tools > Antibodies
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