This technology is a novel rabbit antibody for SIRT2 ( Sirtuin 2) designed to follow human SIRT2 proteins in order to determine their role in gene regulation and apoptosis.
Background & Unmet Need:
The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. Sirtuins have a role in regulation of transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible antineoplastic agents. In addition, Sir2-like family deacetylases are involved in the normal aging process through their role in resistance of cellular stress.
Technology Description:
This invention is a rabbit serum, taken from a rabbit immunized with a 12-amino acid peptide to the carboxyl terminus of the human SIRT2 protein. It was created to follow SIRT2 proteins in human cells, allowing its use as a research tool for cellular and developmental studies.
Commercial Applications:
- Research tool for elucidating the role of human sirtuins in gene regulation and cellular processes
Stage of Development:
Preclinical; cellular studies performed
Competitive Advantages:
- Novel rabbit antibody for SIRT2 that specifically follows human SIRT2 protein
Intellectual Property Status:
No patent information available
Related Publications or Citations of Work:
Dryden SC, Nahhas FA, Nowak JE, Goustin AS, Tainsky MA. (2003) Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol. Cell. Biol. 23:3173-3185.