SIRT2 Antibody

Case ID:
04-684

This technology is a novel rabbit antibody for SIRT2 ( Sirtuin 2) designed to follow human SIRT2 proteins in order to determine their role in gene regulation and apoptosis.

 

Background & Unmet Need:

The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.  Sirtuins have a role in regulation of transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible antineoplastic agents.  In addition, Sir2-like family deacetylases are involved in the normal aging process through their role in resistance of cellular stress.

 

Technology Description:

This invention is a rabbit serum, taken from a rabbit immunized with a 12-amino acid peptide to the carboxyl terminus of the human SIRT2 protein.  It was created to follow SIRT2 proteins in human cells, allowing its use as a research tool for cellular and developmental studies.

 

Commercial Applications:

  • Research tool for elucidating the role of human sirtuins in gene regulation and cellular processes

 

Stage of Development:

Preclinical; cellular studies performed

 

Competitive Advantages:

  • Novel rabbit antibody for SIRT2 that specifically follows human SIRT2 protein

 

Intellectual Property Status:

No patent information available

 

Related Publications or Citations of Work:

Dryden SC, Nahhas FA, Nowak JE, Goustin AS, Tainsky MA.  (2003)  Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol. Cell. Biol. 23:3173-3185.

 

Patent Information:
For Information, Contact:
Joan Dunbar
Associate Vice President for Technology Commercialization
Wayne State University
(313) 577-5542
jcdunbar@med.wayne.edu
Inventors:
Michael Tainsky
Sylvia Dryden
Keywords:
Compound
Protein