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Isoform-selective HDAC inhibitors
Selective C4-modified SAHA analogs inhibit HDAC6 and HDAC8 enzymes for targeted therapeutic applications.
Technology Summary
Histone deacetylase (HDAC) proteins are key players in cancer progression and have emerged recently as targets for anti-cancer drugs. WSU researchers have synthesized a variety of small molecule HDAC...
Published: 6/16/2026
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Inventor(s): Mary Pflum
Keywords(s):
Category(s): Technology Category > Biomedical, Technology Category > Chemical Processing/Synthesis, Technology Category > Characterization, Technology Category > Life Science, Technology Category > Oncology, Technology Category > Pharmaceuticals, Technology Category > Research tools, Technology Category > Small molecule
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Cell permeable ATP analogs
A novel ATP analog featuring a polyamine linker enables efficient kinase-catalyzed biotinylation within live cells by enhancing cell permeability.
Technology Summary
ATP (adenosine 5’-triphosphate) analogs such as ATP-biotin are widely used to monitor biochemical events in vitro. WSU researchers developed a specially...
Published: 6/16/2026
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Inventor(s): Mary Pflum
Keywords(s):
Category(s): Technology Category > Assays, Technology Category > Biology, Technology Category > Life Science, Technology Category > Research tools, Technology Category > Chemical Processing/Synthesis
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Omnidirectional Reflective Photoacoustic Tomography System for High-Resolution Biomedical Imaging
An advanced photoacoustic tomography system providing high-resolution, 360-degree imaging without tissue compression for improved breast cancer screening.
Technology Summary
This technology features an all-reflective optical system that converts collimated light into a converging ring-shaped beam, enabling circumferential illumination of tissue...
Published: 5/12/2026
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Inventor(s): Ivan Avrutsky, Mohammad Mehrmohammadi
Keywords(s): Breast Cancer
Category(s): Technology Category > Life Science, Technology Category > Instrumentation, Technology Category > Imaging, Technology Category > Medical Devices, Technology Category > Acoustics, Technology Category > Optics & Photonics, Technology Category > Cancer, Technology Category > Diagnostics, Technology Category > Spectroscopy
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Liposomal Vancomycin-Cefazolin Nanoparticle for Treating Infections
A novel liposomal nanoparticle delivering vancomycin and cefazolin enhanced with targeting ligands improves treatment efficacy of Staphylococcus aureus infections, including MRSA, while reducing kidney toxicity.
Technology Summary
“Methicillin-resistant Staphylococcus aureus (MRSA) represents one of the most significant...
Published: 4/21/2026
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Inventor(s): Arun Iyer, Michael Rybak, Samaresh Sau, Ketki Bhise, Razie Kebriael
Keywords(s):
Category(s): Technology Category > Life Science, Technology Category > Drug Delivery, Technology Category > Infectious disease, Technology Category > Driving Lifelong Health
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Insulin Crystals Removal Platform
Description:
A platform technology for improving insulin delivery by removing insulin-derived fibrils through polyester membrane filtration.
This invention employs membrane filters integrated into insulin delivery systems to selectively remove insulin-derived fibrils (IDFs) from insulin formulations. By filtering out fibrils while preserving active...
Published: 1/27/2026
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Inventor(s): Ulrike Klueh
Keywords(s):
Category(s): Technology Category > Biomedical, Technology Category > Devices, Technology Category > Drug Delivery, Technology Category > Life Science, Technology Category > Medical Devices
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“Smart” Glucose-Responsive Insulin
Technology Summary
A "smart" or glucose-responsive insulin that can automatically respond to changes in a patient’s blood stream and help treat patients with type 1 diabetes. This technology comprises compositions that integrate a zwitterionic polymer, insulin moieties, saccharide moieties, and saccharide binding molecules to create...
Published: 1/9/2026
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Inventor(s): Zhiqiang Cao
Keywords(s):
Category(s): Technology Category > Biological materials, Technology Category > Chemical Processing/Synthesis, Technology Category > Drug Delivery, Technology Category > Process/Procedure, Technology Category > Small molecule, Technology Category > Therapeutics, Technology Category > Life Science
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Human Tissue-Engineered Inflammatory Model of Atherosclerosis
A novel, biologically engineered human blood vessel model that accurately replicates atherosclerosis for advanced preclinical research.
Technology Summary
This technology creates the first authentic human tissue-level in vitro model of atherosclerosis using a proprietary ring stacking method to build three-layered blood vessels entirely from human...
Published: 1/9/2026
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Inventor(s): Mai Lam
Keywords(s):
Category(s): Technology Category > Biomedical, Technology Category > Research tools, Technology Category > Simulation & Modeling, Technology Category > Driving Lifelong Health, Technology Category > Cardiology, Technology Category > Biomaterials, Technology Category > Life Science
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Portable Thermal Nitric Oxide Generation Technology
Novel chemical composition that enables pure NO gas release upon heat.
Technology Summary
This technology enables safe, efficient, and portable generation of medical-grade nitric oxide (NO) by thermally activating a bench-stable solid-state NO-releasing molecule embedded in a porous polymer matrix. FDA approved Inhaled nitric...
Published: 12/16/2025
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Inventor(s): James Bour, Shuxiao Li
Keywords(s):
Category(s): Technology Category, Technology Category > Medical Devices, Technology Category > Drug Delivery, Technology Category > Driving Lifelong Health, Technology Category > Life Science
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Methods For The Prediction Of Drug Penetration and Exposure In The Human Brain
Description:
A novel 9‑compartment physiologically based pharmacokinetic model was developed and fully validated for prediction of heterogeneous drug distribution and exposure in the human central nervous system (CNS) and brain tumors. The 9-compartment model accounts for the general anatomical structure and pathophysiology of the human CNS and brain...
Published: 11/21/2025
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Inventor(s): Jing Li, Seongho Kim, Charuka Wickramasinghe
Keywords(s):
Category(s): Technology Category > Life Science, Technology Category > Method, Technology Category > Drug Screening, Technology Category > Drug Delivery
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Thermal Atomic Layer Etching of Cobalt and Other Transition Metal Films
A novel stepwise chemical etching method for precise and controlled removal of metal surfaces using protic compounds.
Technology Summary
This technology introduces a method for etching metal or element surfaces by initially contacting the surface with a protic compound to create a modified layer, followed by exposure to a protic ligand-forming compound...
Published: 10/28/2025
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Inventor(s): Charles Winter
Keywords(s):
Category(s): Technology Category > Assays, Technology Category > Chemical Processing/Synthesis, Technology Category > Chemicals, Technology Category > Life Science, Technology Category > Materials, Technology Category > Physical Sciences, Technology Category > Physics, Technology Category > Process/Procedure, Technology Category > Small molecule, Technology Category > Specialty compounds, Technology Category > Thin films
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