Search Results - "Life Science" and "Other"




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Ruthenium-based caging of nitrile-containing enzyme inhibitors
Technology Summary: Novel synthesis methods for caging nitrile-containing bioactive molecules to a non-toxic ruthenium metal complex have been developed which enable light activated release of a cathespin K inhibitor. Numerous potent and selective cathepsin inhibitors are being developed as drug candidates. Cysteine cathepsins are involved in the p...
Published: 4/29/2013   |   Inventor(s): Jeremy Kodanko, Claudia Turro
Keywords(s): Cancer, Pharmaceuticals
Category(s): Chemicals, Drug Delivery, Life Science, Physical Sciences, Other
Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging
Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LS...
Published: 4/26/2013   |   Inventor(s): Sarah Trimpin, Thushani Nikeshala, Ellen Inutan, John Maarouf
Keywords(s): Biotechnology, Imaging
Category(s): Instrumentation, Imaging, Characterization, Other, Physical Sciences, Spectroscopy, Life Science, Research tools
A Flexible Biocompatible Graphene Sensor for Point-of-care Diagnosis
A Wayne State University researcher has developed a novel method applying graphene to sensitive, high-throughput, multiplexing, for label-free and low-cost electrical biosensing applications. Graphene is a flat single layer of sp2 bonded carbon atoms that are packed in a honey comb lattice, and have shown to have exceptional electronic, mec...
Published: 11/23/2011   |   Inventor(s): Mark Ming-Cheng Cheng
Keywords(s):  
Category(s): Materials, Diagnostics, Life Science, Other, MEMS, Nanomaterials, Physical Sciences, Sensors
Nano-beaker array formation process and its use for high-throughput loading and crystallization screening and other lab-on-the-chip applications
Wayne State University researchers have invented a novel process to make array patterns and its use for high-throughput screening of crystallization conditions, liquid solution applications, and other lab-on-the-chip applications. The formation process is a variation of ?particle lithography? in which microparticles such as polystyrene micro...
Published: 11/7/2011   |   Inventor(s): Guangzhao Mao, Daniel Sobczynski, Sunxi Wang, Eugene Xhahysa, Pedram Jahanian
Keywords(s): Nanotechnology
Category(s): Physical Sciences, Microfluidics, MEMS, Life Science, Research tools, Other
GlyB4 Fusion with Neuregulin Heparin-Targeting Domain to Block Neuregulin Signaling
We have harnessed this natural targeting ability of NRG by fusing the HBD of NRG to soluble HER4. This fusion protein retains high affinity heparin binding to heparin and to cells that express heparan sulfates resulting in a more potent NRG antagonist. In vivo, it is targeted to peripheral nerve segments where it blocks the activity of NRG as a Sch...
Published: 5/16/2011   |   Inventor(s): Jeffrey Loeb, Qunfang Lee
Keywords(s): Anti-cancer, Biotechnology, Cancer risk, Cancer Therapies, Drug Delivery, Drug Target, Epilepsy
Category(s): Life Science, Drug Delivery, Other
Novel Biosensor Based on Parylene Cantilevers
A Wayne State University researcher has developed a novel biosensor for DNA and protein microarray applications as well as lab-on-a-chip assays. The biosensor is composed of a micro-scale cantilever made of a polymer material with a modulus of elasticity significantly less than cantilever-based biosensors utilizing silicon nitride. Biosensors base...
Published: 5/13/2010   |   Inventor(s): Yong Xu
Keywords(s): Device
Category(s): Life Science, Physical Sciences, Diagnostic, Other, Sensors
Magnetic Resonance Force Microscopy for Molecular Imaging
This technology involves using refined Magnetic Resonance Force Microscopy (MRFM) to study biological systems such as isolated cells, sub-cellular organelles, and other sub-cellular structures or cellular receptors and proteins at resolutions ranging from 1 micron to 1 angstrom. MRFM has the potential to significantly impact biomedical research an...
Published: 5/13/2010   |   Inventor(s): Stanley Fricke, Gregory Moore
Keywords(s): Imaging
Category(s): Life Science, Research tools, Other