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Ruthenium-based caging of nitrile-containing enzyme inhibitors

Technology Summary: Novel synthesis methods for caging nitrile-containing bioactive molecules to a non-toxic ruthenium metal complex have been developed which enable light activated release of a cathespin K inhibitor. Numerous potent and selective cathepsin inhibitors are being developed as drug candidates. Cysteine cathepsins are involved in the pathophysiology...

Published: 10/27/2023 | Inventor(s): Jeremy Kodanko, Claudia Turro

Keywords(s): Cancer, Pharmaceuticals

Category(s): Chemicals, Drug Delivery, Life Science, Physical Sciences, Other

Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging

Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI...

Published: 5/1/2018 | Inventor(s): Sarah Trimpin, Thushani Nikeshala, Ellen Inutan, John Maarouf

Keywords(s): Biotechnology, Imaging

Category(s): Instrumentation, Imaging, Characterization, Other, Physical Sciences, Spectroscopy, Life Science, Research tools

Nano-beaker array formation process and its use for high-throughput loading and crystallization screening and other lab-on-the-chip applications

Wayne State University researchers have invented a novel process to make array patterns and its use for high-throughput screening of crystallization conditions, liquid solution applications, and other lab-on-the-chip applications. The formation process is a variation of “particle lithography” in which microparticles such as polystyrene microparticles...

Published: 9/17/2019 | Inventor(s): Guangzhao Mao, Daniel Sobczynski, Sunxi Wang, Eugene Xhahysa, Pedram Jahanian

Keywords(s): Nanotechnology

Category(s): Physical Sciences, Microfluidics, MEMS, Life Science, Research tools, Other

GlyB4 Fusion with Neuregulin Heparin-Targeting Domain to Block Neuregulin Signaling

We have harnessed this natural targeting ability of NRG by fusing the HBD of NRG to soluble HER4. This fusion protein retains high affinity heparin binding to heparin and to cells that express heparan sulfates resulting in a more potent NRG antagonist. In vivo, it is targeted to peripheral nerve segments where it blocks the activity of NRG as a Schwann...

Published: 12/6/2022 | Inventor(s): Jeffrey Loeb, Qunfang Lee

Keywords(s): Anti-cancer, Biotechnology, Cancer risk, Cancer Therapies, Drug Delivery, Drug Target, Epilepsy

Category(s): Life Science, Drug Delivery, Other

Magnetic Resonance Force Microscopy for Molecular Imaging

This technology involves using refined Magnetic Resonance Force Microscopy (MRFM) to study biological systems such as isolated cells, sub-cellular organelles, and other sub-cellular structures or cellular receptors and proteins at resolutions ranging from 1 micron to 1 angstrom. MRFM has the potential to significantly impact biomedical research and...

Published: 3/2/2022 | Inventor(s): Stanley Fricke, Gregory Moore

Keywords(s): Imaging

Category(s): Life Science, Research tools, Other