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A method to induce ferroptosis and to downregulate androgen receptor/androgen receptor splice variant in prostate cancer cells

Prostate cancer (PCa) effects approximately three million men in the United States every year. About 10-20% of the cases of prostate cancer are castrate-resistant prostate cancer (CRPC). This form of PCa is highly resistant to what Is known as androgen depletion therapy and is often fatal. All types of PCa are sensitive to androgen receptor signaling...

Published: 11/19/2020 | Inventor(s): Zhihui Qin, Liping Xu

Keywords(s): Anti-cancer, Cancer, Cancer Therapies, Drug Delivery, Drug Target, Prostate Cancer

Category(s): Medical, Diseases, Drug Discovery, Pharmaceuticals, Oncology

Ultra-Specific and Ultra-Sensitive Platform for Highly-Reliable and High-Precision SARS-CoV-2 Detection

Background:The technology described is based on the use of two unique sets of detection molecules that are specific to a protein contained in the viral shell of SARS CoV-2 and Covid-19 that is unique from other known common cold causing coronaviruses. The proposed system uses two different fluorescent probes for two different regions of the viral shell...

Published: 5/26/2020 | Inventor(s): Rodrigo Fernandez-Valdivia

Keywords(s): Coronavirus, COVID-19, Diagnostic, Virus

Category(s): Diagnostic, Biomedical, Medical, Diseases, Infectious disease

Topical treatment with TGFbeta3 to facilitate skin and corneal wound healing in diabetic patients

Background: Diabetes affects approximately 170 million people worldwide, including 20.8 million in the USA, and by 2030 these numbers are projected to double. Diabetics often experience slow or limited wound healing. Slow wound healing allows longer time for the development of infections and can contribute to the formation of bed sores and ulcers....

Published: 3/12/2018 | Inventor(s): Fu-Shin Yu

Keywords(s): Diabetes

Category(s): Medical, Biologicals, Biomedical, Drug Discovery, Metabolic disorders, Protein/peptides, Therapeutics, Life Science

User-Friendly Displays of Patient-Reported Outcome Data

User-Friendly Displays of Patient-Reported Outcome Data WSU Tech#: 14-1216 Technology Summary: Patients can use tablet devices to take daily web based surveys regarding symptoms. Algorithm analyzes and transforms data into a single display of patient reported outcomes. This operationalizes subjective qualitative patient-reported information (quality...

Published: 5/19/2017 | Inventor(s): Felicity Harper, Louis Penner, Richard Gonzalez

Keywords(s):

Category(s): Medical, Software, Computer Software

Secure Aliquoting Machine (SAM): An error free automated system for labeling and aliquoting clinical samples

Safe, Simple, Speedy Sample Transferring System (4STS) WSU Tech#: 14-1202 Technology Summary: The Vacutainer blood collection tubes (BD) have been optimized for various tests. One of the innovations in the Vacutainer collection tubes is the addition of a special gel to the tube that allows the separation of serum or plasma from cellular component...

Published: 5/19/2017 | Inventor(s): Hossein Salimnia

Keywords(s):

Category(s): Medical, Biomedical, Devices, Medical Devices

Easy Cell Block Device for Cytopathology and Surgical Pathology Specimens

Cell Block Device for Cytopathology and Surgical Pathology Specimens WSU Tech#: 13-1174 Technology Summary: Preparation of cell blocks is indicated from swaps or collected fluids where cells or small tissue fragments are examined. Veterinary sciences and many research labs also need good methodology to prepare high quality cell blocks with...

Published: 5/19/2017 | Inventor(s): Vinod Shidham, Anjani Shidham

Keywords(s):

Category(s): Medical, Biomedical, Diagnostic, Microscopy

Targeted Drug Delivery for Spinal Cord Injury

Technology Summary: WSU researchers have developed a new nanoparticle-drug conjugate for treating cervical spinal cord injury (SCI) that can restore respiratory function to the paralyzed hemi diaphragm. Using the nano-conjugate enables targeted delivery of the drug directly to the respiratory centers resulting in dramatically lower effective dosages...

Published: 5/19/2017 | Inventor(s): Harry Goshgarian, Guangzhao Mao, Yi Zou, Sunxi Wang

Keywords(s): Central Nervous System, Drug Delivery, Neuroscience, Therapeutics

Category(s): Therapeutics, Life Science, Drug Delivery, Medical, Chemical Processing/Systhesis, Nanomaterials, Neurological disorders, Receptors/targets

Level of Galectin-3 protein in human blood improves PSA test results

Level of Galectin-3 Protein in Human Blood Improves PSA Test Results WSU Tech#: 13-1133 Technology Summary: For determining prostate cancer aggressiveness, PSA alone is not reliable, as it gives a high number of false positive and false negative results. There are about 25,000 publications on other markers in addition to PSA and as of yet, none...

Published: 5/19/2017 | Inventor(s): Avraham Raz, Vitaly Balan, Elisabeth Heath, Lance Heilbrun

Keywords(s):

Category(s): Medical, Biomedical, Diagnostics, Oncology

A method to identify patients at risk for subsequent stillbirth in the third trimester

A Method to Identify and Treat Patients at Risk for Stillbirth in the 3rd TrimesterWSU Tech#: 12-1113Technology Summary: This invention is a method of identifying patients at risk for subsequent stillbirth (only due to placental related disorder) in the third trimester using a maternal blood sample. A blood sample would be obtained at the beginning...

Published: 5/19/2017 | Inventor(s): Tinnakorn Chaiworapongsa, Roberto Romero, Sonia Hassan

Keywords(s):

Category(s): Medical, Diagnostic, Prenatal, Small molecule, Specialty compounds, Therapeutics, Life Science

Development of a multimolecular and multimodular biomarker panel for the early screening, molecular distinction and clinical follow-up of patients developing preeclampsia/HELLP syndrome and its preparation for preclinical testing

Development of a Multimolecular and Multimodular Biomarker Panel for the Early Screening, Molecular Distinction and Clinical Follow-Up of Patients Developing Preeclampsia/HELLP Syndrome and its Preparation for Preclinical Testing WSU Tech#: 12-1110 Technology Summary: Preeclampsia is a pregnancy complication characterized by high blood pressure and...

Published: 5/19/2017 | Inventor(s): Nandor Than, Adi Tarca, Gabor Juhasz, Adrienna Kekesi, Hamutal Meiri, Zoltan Papp, Roberto Romero

Keywords(s):

Category(s): Medical, Biotechnology, Diagnostic, Diagnostics, Genomics/Genetics, Prenatal, Proteomics

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